L-Carnitine
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- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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L-Carnitine Solution – 10ml (600mg)
L-Carnitine is a naturally occurring quaternary ammonium compound essential for fatty acid transport into mitochondria. It plays a central role in mitochondrial energy metabolism, supporting the oxidation of long-chain fatty acids and contributing to ATP production. L-Carnitine is endogenously synthesized from lysine and methionine and is also obtained through dietary sources. Research interest focuses on its roles in energy homeostasis, muscle physiology, cardiovascular function, and neuroprotection.
Overview
L-Carnitine functions as a carrier molecule, forming acyl-carnitine esters to shuttle long-chain fatty acids across the mitochondrial inner membrane for β-oxidation. This process is critical for energy generation, particularly in tissues with high energy demand such as skeletal muscle, myocardium, and the liver.
Experimental studies also suggest L-Carnitine supports antioxidant activity by buffering excess acyl-CoA and reducing oxidative stress, contributing to cellular protection under metabolic stress conditions. Research models have evaluated its potential benefits in exercise physiology, cardiovascular disorders, insulin resistance, and neurological health.
Chemical Makeup
- Molecular Formula: C7H15NO3
- Molecular Weight: 161.2 g/mol
- Structure: β-hydroxy-γ-trimethylaminobutyric acid
- Concentration: 60mg/ml (600mg total in 10ml vial)
- Other Known Titles: Levocarnitine, L-3-hydroxy-4-trimethylaminobutyrate
Research and Clinical Studies
Mitochondrial Energy Metabolism
L-Carnitine is critical for mitochondrial β-oxidation of fatty acids, maintaining energy balance during fasting, exercise, and metabolic stress. Deficiency models demonstrate impaired fatty acid oxidation and energy production, emphasizing its role as an essential mitochondrial cofactor.
Cardiovascular Function
Research suggests L-Carnitine supplementation may improve cardiac energy efficiency, protect against ischemia-reperfusion injury, and reduce markers of oxidative damage in myocardial tissue.
Exercise and Muscle Recovery
In muscle physiology studies, L-Carnitine administration has been linked to reduced exercise-induced lactate accumulation, enhanced oxygen utilization, and faster muscle recovery.
Neurological Models
Acetyl-L-carnitine derivatives have been examined for their role in neuroprotection, mitochondrial stabilization, and improvement of cognitive performance in models of neurodegenerative disorders.
Insulin Sensitivity and Metabolism
Animal and human studies indicate L-Carnitine may improve glucose tolerance and insulin sensitivity by facilitating fatty acid oxidation and reducing intramyocellular lipid accumulation.
L-Carnitine solution is available for research and laboratory purposes only. Not for human consumption.
References
- Rebouche CJ, Seim H. Carnitine metabolism and its regulation in microorganisms and mammals. Annu Rev Nutr. 1998;18:39–61. https://pubmed.ncbi.nlm.nih.gov/9706218/
- Bremer J. Carnitine — metabolism and functions. Physiol Rev. 1983;63(4):1420–1480. https://pubmed.ncbi.nlm.nih.gov/6359186/
- Stanley CA. Carnitine deficiency disorders in children. Ann N Y Acad Sci. 2004;1033:42–51. https://pubmed.ncbi.nlm.nih.gov/15590996/
- Brass EP. Pharmacokinetic considerations for carnitine supplementation. Clin Ther. 1995;17(5):800–810. https://pubmed.ncbi.nlm.nih.gov/8847158/
- Calabrese V, et al. Acetyl-L-carnitine and neuroprotection. Mech Ageing Dev. 2006;127(6):492–504. https://pubmed.ncbi.nlm.nih.gov/16507360/
- Mingorance C, et al. Role of carnitine in exercise and energy metabolism. J Physiol Biochem. 2011;67(1):13–21. https://pubmed.ncbi.nlm.nih.gov/21249482/
- Arduini A, et al. L-Carnitine and protection against oxidative stress in heart and skeletal muscle. Free Radic Biol Med. 2008;44(8):1385–1394. https://pubmed.ncbi.nlm.nih.gov/18206666/
- Malaguarnera M. Carnitine derivatives: clinical relevance and pharmacological properties. Nutrients. 2019;11(9):2084. https://pubmed.ncbi.nlm.nih.gov/31514493/
- Longo N, et al. Primary and secondary carnitine deficiency syndromes. Am J Med Genet C Semin Med Genet. 2006;142C(2):77–85. https://pubmed.ncbi.nlm.nih.gov/16602102/
- Pignatti C, et al. Role of carnitine in human nutrition and metabolism. Nutrients. 2020;12(1):228. https://pubmed.ncbi.nlm.nih.gov/31906210/
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