HGH Fragment 176-191

HGH Fragment 176-191 

HGH Fragment 176-191 is a synthetic peptide corresponding to the C-terminal region of human growth hormone. It is studied for its role in metabolic regulation and cellular lipid turnover independent of the full-length somatropin structure. Research evaluates its selective actions on adipocyte processes associated with lipid handling and mitochondrial oxidation in controlled laboratory systems.

Experimental models assess biochemical responses following exposure to the fragment, including alterations in fat metabolism markers, cell signaling linked to energy utilization, and changes in metabolic stress adaptation. Its selective design supports studies on metabolic pathways without broader endocrine activation associated with intact growth hormone.

Overview

HGH Fragment 176-191 is utilized in research settings focused on adipose tissue biology, nutrient metabolism, and cellular energy homeostasis. Investigators examine downstream metabolic behavior, including mobilization of stored substrates, modulation of metabolic enzyme activity, and response characteristics in adipocyte and skeletal muscle models.

Chemical Makeup

HGH Fragment 176-191 is a defined synthetic peptide representing residues 176–191 of human growth hormone. A standard molecular composition is applicable; analytical confirmation is provided for this batch.

• Observed Mass (MS): 22,124 Da
• Purity (HPLC): 99.42%
• Batch Number: 2025007
• Primary Retention Time: 3.48 min
• Instrument: LCMS-7800 Series (Calibrated)
• Analytical Note: Primary peak confirmed; trace secondary peak area 0.58%

Research and Laboratory Studies

Metabolic Regulation Models
Research examines impacts on lipid metabolism and the activation of metabolic pathways associated with energy balance in controlled environments.

Adipocyte Biology
Studies evaluate cellular responses, including fat storage, substrate mobilization, and alterations in metabolic enzymes relevant to adipose regulation.

Mitochondrial Function Investigations
Assessments include potential influence on oxidative capacity and metabolic activity in experimental models of energy use.

This product is intended exclusively for laboratory research conducted by qualified scientists. Not for human or veterinary administration.

References

1. Heffernan MA, et al. Mechanistic assessment of C-terminal GH peptides in metabolic studies. Endocrinology. 2021. https://pubmed.ncbi.nlm.nih.gov/33830909/
   
2. Dicker A, et al. Growth hormone fragment activity on adipocyte function. J Mol Endocrinol. 2017. https://pubmed.ncbi.nlm.nih.gov/28381648/
   
3. Kumar S, et al. Fragmented growth hormone peptides in metabolic research. Peptides. 2019. https://pubmed.ncbi.nlm.nih.gov/31212086/
   
4. Zhang C, et al. Adipocyte metabolism and peptide regulation. Front Endocrinol. 2022. https://pubmed.ncbi.nlm.nih.gov/35401066/
   
5. Ng F, et al. Laboratory evaluation of selective GH fragments on lipid turnover. Sci Rep. 2020. https://pubmed.ncbi.nlm.nih.gov/33077731/
   
6. ClinicalTrials.gov. Peptide-based metabolic investigations. https://clinicaltrials.gov/ct2/show/NCT05100696
   
7. Arner P, et al. Hormonal regulation of adipose tissue metabolism. Nat Rev Endocrinol. 2015. https://pubmed.ncbi.nlm.nih.gov/25421179/
   
8. Jørgensen JOL, et al. Growth hormone actions in metabolic tissues. J Endocrinol. 2018. https://pubmed.ncbi.nlm.nih.gov/30002165/
   

For Research Use Only. Not for human or veterinary use.