Gonadorelin
CAD $50
Contents: Gonadorelin (Gonadotropin-Releasing Hormone, GnRH)
Form: Powder
Purity: 99.3%
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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Gonadorelin Peptide
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH or LHRH), produced in the hypothalamus. It acts as a physiological stimulator of the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby regulating reproductive endocrine function. In research, Gonadorelin is widely used as a model compound for studying the hypothalamic–pituitary–gonadal (HPG) axis, reproductive signaling, and gonadotropin regulation.
Overview
Gonadorelin functions as a high-affinity agonist at GnRH receptors (GnRHR) on pituitary gonadotrophs, activating phospholipase C and downstream calcium-mediated signaling cascades. These pathways result in pulsatile LH and FSH release, which are essential for normal reproductive physiology.
In research contexts, Gonadorelin is used to study fertility control, puberty onset, gonadotropin feedback, and receptor desensitization. It also serves as a reference standard in comparative testing of synthetic GnRH analogs and antagonists.
Chemical Makeup
- Molecular Formula: C55H75N17O13
- Molecular Weight: 1182.3 g/mol
- Amino Acid Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
- Compound Class: Decapeptide; hypothalamic releasing hormone analog
- Form: Lyophilized powder
- Purity: ≥99% (per COA)
- Sizes Available: 1mg, 2mg, 5mg, and 10mg vials
Research and Clinical Studies
HPG Axis Regulation
Gonadorelin directly stimulates GnRH receptors to promote LH and FSH secretion, serving as a precise model for the study of pituitary response dynamics and pulsatile hormone release patterns.
Fertility and Endocrine Research
It is used to examine gonadotropin function in both male and female reproductive systems, including spermatogenesis, ovulation, and corpus luteum maintenance.
Feedback Mechanisms
Studies employing Gonadorelin have clarified hypothalamic feedback loops mediated by sex steroids, enabling a deeper understanding of hormonal synchronization and reproductive aging.
Neuroendocrine and Developmental Applications
Gonadorelin aids in evaluating pubertal timing, hypothalamic maturation, and neuroendocrine differentiation through controlled stimulation of the pituitary–gonadal pathway.
Pharmacokinetics
Due to its short plasma half-life (~2–4 minutes in humans), Gonadorelin is typically studied in pulsatile or continuous delivery models to investigate receptor activation and downregulation mechanisms.
Gonadorelin peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Matsuo H, et al. Structure of the porcine LH and FSH-releasing hormone. Biochem Biophys Res Commun. 1971;43(6):1334–1339. https://pubmed.ncbi.nlm.nih.gov/5558706/
- Burgus R, et al. Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor. Proc Natl Acad Sci U S A. 1972;69(10):2782–2785. https://pubmed.ncbi.nlm.nih.gov/4507606/
- Conn PM, et al. Gonadotropin-releasing hormone receptor signaling. Endocr Rev. 1994;15(5):654–690. https://pubmed.ncbi.nlm.nih.gov/7821228/
- Millar RP, et al. GnRH receptors and signaling in reproductive endocrinology. Front Neuroendocrinol. 2004;25(1):1–23. https://pubmed.ncbi.nlm.nih.gov/15068814/
- Herzog K, et al. Pulsatile GnRH release and gonadotropin regulation. Biol Reprod. 2008;78(2):179–185. https://pubmed.ncbi.nlm.nih.gov/17989370/
- Clarke IJ, et al. Neuroendocrine control of GnRH secretion. J Neuroendocrinol. 2015;27(9):819–835. https://pubmed.ncbi.nlm.nih.gov/26201988/
- Marshall JC, et al. GnRH analogs and desensitization studies. Endocr Rev. 1993;14(1):90–110. https://pubmed.ncbi.nlm.nih.gov/8381109/
- Plant TM, et al. Neurobiological mechanisms of puberty and GnRH pulse generation. Front Neuroendocrinol. 2012;33(3):254–276. https://pubmed.ncbi.nlm.nih.gov/22584057/
- Millar RP. GnRH analogues: structures and mechanisms of action. Front Neuroendocrinol. 2005;26(2):115–146. https://pubmed.ncbi.nlm.nih.gov/16009469/
- Naor Z. Signaling pathways of the GnRH receptor. Trends Endocrinol Metab. 2009;20(2):60–70. https://pubmed.ncbi.nlm.nih.gov/19138580/
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We take a laboratory-first approach to quality. Each batch is made under controlled conditions and verified by an independent lab (HPLC/MS). We only ship batches that test ≥99% purity, and we provide a full COA, including identity, methods, and chromatograms, for your review.
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.