KPV Tripeptide
From CAD $50 CAD $69
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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KPV 10mg
KPV is a tripeptide fragment derived from the alpha-melanocyte-stimulating hormone (α-MSH), composed of the amino acids Lysine-Proline-Valine. This sequence is recognized for its potential anti-inflammatory and immunomodulatory activity in experimental models. KPV has been studied for its possible ability to influence gut integrity, inflammatory signaling pathways, and overall epithelial health.
Overview
Research suggests that KPV may interact with melanocortin receptor pathways, which are hypothesized to regulate immune and inflammatory responses. In laboratory models, KPV has been associated with reduced activity of pro-inflammatory cytokines, potentially helping to preserve barrier function in intestinal tissue. This peptide is being investigated for its possible role in modulating responses to inflammatory insults and promoting recovery in conditions linked to epithelial dysfunction.
Beyond gastrointestinal research, KPV has been explored for its potential to mitigate systemic inflammation, oxidative stress, and localized tissue damage, pointing to broader applications across multiple biological systems.
Chemical Makeup
- Molecular Formula: C17H29N5O4
- Molecular Weight: 371.44 g/mol
- Sequence: H-Lys-Pro-Val-OH
- Appearance: White lyophilized powder
- Purity: ≥ 98% (HPLC, batch-certified)
Research and Experimental Findings
KPV and Gut Inflammation
Experimental studies suggest that KPV may attenuate intestinal inflammation by downregulating inflammatory cytokines and enhancing epithelial recovery. Murine colitis models showed improved histological scores and reduced inflammatory infiltration following KPV administration, pointing to its potential relevance in gut mucosal defense.
KPV and Antimicrobial Properties
KPV has been observed to exhibit antimicrobial potential, particularly against bacterial overgrowth in intestinal models. This may involve disrupting microbial adhesion or biofilm formation while simultaneously protecting host epithelial cells.
KPV and Skin Barrier Integrity
Although primarily studied in gastrointestinal contexts, research indicates that KPV may also support epithelial barrier function in skin models, suggesting broader potential applications for mucosal and epithelial repair research.
Storage and Handling
- Store lyophilized peptide at −20°C in a dry environment.
- Reconstitute in sterile water or buffer immediately prior to use.
- After reconstitution, aliquot to avoid repeated freeze-thaw cycles.
References
- Catania A, et al. The neuropeptide alpha-MSH in host defense. Ann N Y Acad Sci. 1999;885:149–170. https://pubmed.ncbi.nlm.nih.gov/10816650/
- Getting SJ. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends Pharmacol Sci. 2002;23(10):447–449. https://pubmed.ncbi.nlm.nih.gov/12368067/
- Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol Today. 1997;18(4):140–145. https://pubmed.ncbi.nlm.nih.gov/9139458/
- Star RA, et al. Melanocortin peptide therapy of experimental inflammatory bowel disease. Gastroenterology. 1998;114(5):923–932. https://pubmed.ncbi.nlm.nih.gov/9558275/
- Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev. 1993;14(5):564–576. https://pubmed.ncbi.nlm.nih.gov/8262000/
- Getting SJ, et al. Melanocortin peptides and their receptors in inflammation and disease. Endocr Metab Immune Disord Drug Targets. 2006;6(3):193–203. https://pubmed.ncbi.nlm.nih.gov/17017852/
- Brzoska T, et al. Melanocortins: multiple actions on skin barrier function. Exp Dermatol. 2008;17(9):793–803. https://pubmed.ncbi.nlm.nih.gov/18476927/
- Ceriani G, et al. The neuropeptide alpha-MSH exerts immunomodulatory and antimicrobial actions in experimental models. Peptides. 2006;27(6):1835–1843. https://pubmed.ncbi.nlm.nih.gov/16386495/
- Catania A, et al. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840–1853. https://pubmed.ncbi.nlm.nih.gov/20862381/
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We take a laboratory-first approach to quality. Each batch is made under controlled conditions and verified by an independent lab (HPLC/MS). We only ship batches that test ≥99% purity, and we provide a full COA, including identity, methods, and chromatograms, for your review.
See the Process for Yourself
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Science Behind Our Peptides
A clear explanation of how our peptides work, their benefits, why quality matters for best results, and what you should know.
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.