Kisspeptin-10
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- ENDOTOXINS(LPS)
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Kisspeptin-10 Peptide – 10mg
Kisspeptin-10 is a decapeptide fragment of the full-length Kisspeptin protein, a product of the KISS1 gene, and a potent endogenous ligand for the G-protein coupled receptor GPR54 (KISS1R). It is a critical regulator of the hypothalamic-pituitary-gonadal (HPG) axis and has been extensively studied for its role in the initiation of puberty, gonadotropin release, reproductive function, and tumor metastasis suppression.
Overview
Kisspeptins are a family of neuropeptides derived from a larger precursor, with Kisspeptin-10 representing the minimal biologically active sequence. Binding to KISS1R stimulates the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, thereby regulating downstream luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Kisspeptin-10 is widely used as a research tool for studying reproductive endocrinology, fertility regulation, neuroendocrine signaling, and cancer biology. It has also been investigated in metabolic and behavioral studies due to its role in linking energy homeostasis with reproductive function.
Chemical Makeup
- Molecular Formula: C64H86N16O13S
- Molecular Weight: 1302.5 g/mol
- Amino Acid Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
- Other Known Titles: Metastin(45-54), Kp-10, KISS1-derived decapeptide
- Amount: 10mg per vial
- Purity: ≥99% (per COA)
Research and Clinical Studies
Reproductive Endocrinology
Kisspeptin-10 has been shown to directly stimulate GnRH release, initiating LH and FSH secretion. Preclinical and clinical studies have confirmed its role as a master regulator of puberty onset and reproductive function, making it a valuable model peptide in fertility research.
Hypothalamic-Pituitary-Gonadal Axis Regulation
KISS1R activation by Kisspeptin-10 demonstrates robust LH pulses and gonadotropin surges in animal and human studies, supporting its use in investigating hypothalamic neuroendocrine control mechanisms.
Cancer and Metastasis Suppression
The KISS1 gene was first identified as a metastasis suppressor in melanoma and breast cancer. Research indicates that Kisspeptins modulate cell migration and invasion, contributing to oncology research.
Metabolic and Behavioral Research
Studies link Kisspeptin signaling to metabolic cues and reproductive status, with evidence of roles in energy balance, sexual behavior, and mood regulation, offering a model to explore neuroendocrine interactions.
Neuroendocrine Applications
Because Kisspeptin-10 crosses the blood-brain barrier and acts rapidly, it has become a preferred model peptide for acute neuroendocrine and reproductive signaling studies.
Kisspeptin-10 peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Lee DK, et al. Discovery of a novel G protein–coupled receptor related to the galanin receptor family. Endocrinology. 1999;140(2):583–590. https://pubmed.ncbi.nlm.nih.gov/9927279/
- Kotani M, et al. The metastasis suppressor gene product KISS1 is the ligand of a G-protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631–34636. https://pubmed.ncbi.nlm.nih.gov/11457843/
- Seminara SB, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614–1627. https://pubmed.ncbi.nlm.nih.gov/14573733/
- Navarro VM, et al. Kisspeptins: essential gatekeepers of puberty and reproduction. Endocr Rev. 2012;33(6):686–727. https://pubmed.ncbi.nlm.nih.gov/22968818/
- Messager S, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release. Proc Natl Acad Sci U S A. 2005;102(5):1761–1766. https://pubmed.ncbi.nlm.nih.gov/15665093/
- Clarkson J, Herbison AE. Postnatal development of kisspeptin neurons in the mouse hypothalamus. J Neurosci. 2006;26(19):4986–4995. https://pubmed.ncbi.nlm.nih.gov/16687499/
- Jayasena CN, et al. Kisspeptin-10 administration stimulates LH and FSH release in men. J Clin Endocrinol Metab. 2009;94(2):545–550. https://pubmed.ncbi.nlm.nih.gov/19017760/
- Hori A, et al. KISS1 as a metastasis suppressor gene. Int J Cancer. 2001;92(4):529–534. https://pubmed.ncbi.nlm.nih.gov/11304692/
- Dhillo WS, et al. Kisspeptin-10 as a tool for reproductive hormone testing in women. J Clin Endocrinol Metab. 2007;92(8):3125–3131. https://pubmed.ncbi.nlm.nih.gov/17504907/
- d’Anglemont de Tassigny X, et al. Role of kisspeptin signaling in reproductive neuroendocrinology. Nat Rev Endocrinol. 2010;6(10): 564–574. https://pubmed.ncbi.nlm.nih.gov/20720541/
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.